Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH.br
Strain Synonyms: MDC-04-48; ACI
Will grow transplantable Morris hepatomas 3924A which can be used as a model for the treatment of liver cancer. Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumours 46% testes,16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21%pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophictestes on the same side. These abnormalities have a polygenic mode of inheritance. Spontaneous adenocarcinomas of ventral prostate seen in 7/41 untreated males at 34-37 months. This is substantially increased by a high fat diet. High survival to 2 years of age at 74% (rank 2/5) in males and 70% (rank 1/5) in females. However, a high incidence of relatively mild chronic renal disease and a high incidence of hydronephrosis and the congenital renal agenesis may make the strain unsuitable for long-term toxicological studies. Four spontaneous kidney and five bladder tumours found among a cohort of 300 rats maintained for 30 months. Urolithiasis seen in 2/55 rats at an average age of 144 days. A diet deficient in choline and methionine has been used to develop a rat model of fatty liver transplantation.