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Model Characteristics - Model:
Tg(Igh-Maf)524Staka
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| Model Descriptor |
Tg(Igh-Maf)524Staka
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| Official Nomenclature |
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| Genotype |
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| Species |
Mouse (Mus musculus)
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| Strain |
C57BL/6
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that express c-Maf specifically in the B-cell compartment.
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| Phenotype |
In this study, we have generated c-Maf TG mice that overexpress c-Maf in the B-cell compartment, using the Igh promoter and Eμ enhancer. We found that these mice developed B-cell lymphoma, which provided the first direct evidence that c-Maf can function as an oncogene in a murine model of the t(14;16)(q32;q23) translocation. Aged c-Maf TG mice developed B-cell lymphomas with some clinical features that resembled those of MM, namely, plasma cell expansion and hyperglobulinemia. Quantitative RT-PCR analysis demonstrated that Ccnd2 and Itgb7, which are known target genes of c-Maf, were highly expressed in the lymphoma cells. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Takahashi*, Satoru
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| Comment |
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| Model Availability: This model is available from |
| Strain |
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 Comments (Please login to submit new comments) |
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