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Model Characteristics - Model:
Chordomas in Fischer 344 rats
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| Model Descriptor |
Chordomas in Fischer 344 rats
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| Official Nomenclature |
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| Genotype |
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| Species |
Rat (Rattus norvegicus)
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| Strain |
F344
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Chordomas are uncommon axial skeletal neoplasms that arise from residual foci of primitive notochord. In humans, residual notochord has been identified in the nucleus pulposus of the intervertebral discs, peripheral zones of vertebral bodies, including the sacrum, and the spheno-occipital region of the skull. Chordomas may arise anywhere along the vertebral column, but most commonly involve the cranial and caudal limits of the axial skeleton. The approximate distributions of chordomas in humans are: sacrococcygeal, 50%; vertebral, 15%; and sphenoid region of the cranium, 35%. Chordomas have been reported in humans, rat, mice, dogs, and mink. Chordoma in rats has a distinctive histologic appearance and has many features in common with chordoma in humans.
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| Phenotype |
Tissue sections and records of 56 rats with chordoma, identified in the National Toxicology Program's (NTP) data base of approximately 115,000 rats, were examined to determine morphological characteristics, incidence, and aspects of biological behavior. Chordomas occurred in aged rats, originated predominantly in lumbosacral vertebrae, were highly malignant, occurred three times more often in male versus female rats, and commonly produced bilateral posterior paresis, paralysis, and/or distention of the colon and rectum.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Both Sexes
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Giles*, H.D.
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
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