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Model Characteristics - Model:
Systemic external microwave hyperthermia treatment of pleural metastasis in orthotopic mouse lung cancer model
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| Model Descriptor |
Systemic external microwave hyperthermia treatment of pleural metastasis in orthotopic mouse lung cancer model
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| Official Nomenclature |
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| Genotype |
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| Species |
Mouse (Mus musculus)
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| Strain |
nu/nu
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
External microwave (EMW) hyperthermia system (2.45 GHz wave frequency) was evaluated by in vivo pleural metastasis animal model. After optimization of the heating intensity for in vivo environment, we created pleural metastatic animal model in 24 immune deficiency mice (male nu/nu mice) to evaluate inhibitory effect of systemic EMW hyperthermia for disseminated tumor growth. Out of 24 mice, 8 received mild and 8 received moderate hyperthermia, and remaining 8 were the no treatment control. Whole chest area of the experimental animals was irradiated 3 times a week for 2 weeks (total of 6 time irradiations).
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| Phenotype |
No significant adverse event was observed including abnormal weight loss, skin burn, ulceration, and death. Metastasized tumors around the pleura and chest cavity were 75% reduced in size and weight compared to non-treated control group. Harvested tumors were stained and TUNEL assay demonstrated significant apoptosis in a moderate hyperthermia group. The EMW hyperthermia system may be possible alternative tool as a systemic hyperthermia therapy in severely advanced lung cancer patients. Further study is necessary to determine device safeness, efficacy, and synergistic effect to other possible combination therapies.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Male Only
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Nose*, Yukihiko
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
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