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Model Characteristics - Model:
Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
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| Model Descriptor |
Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
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| Official Nomenclature |
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| Genotype |
AJ x Trp53F2-10/F2-10;Rb1F19/F19
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| Species |
Mouse (Mus musculus)
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| Strain |
A/J - mixed
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Almost all mouse models of lung cancer produce adenomas and adenocarcinomas. Recently, Meuwissen et al. generated mice with conditionally targeted alleles for both Rb1 and p53 that developed aggressive lung tumors with high incidence and with striking morphologic and immunophenotypic similarities to SCLC. Rb1 and p53 alleles were conditionally inactivated in the lung epithelium by using adenovirus-mediated somatic gene transfer of Cre recombinase.
In the present study, we examined the effect of bexarotene (Targretin) and budesonide in the chemoprevention of small cell lung carcinoma using a lung-specific knockout model of Rb1 and p53.
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| Phenotype |
Upon treatment with bexarotene, tumor incidence, number, and load were significantly reduced (P < 0.05). Budesonide treatment trended to inhibition, but the effect was not statistically significant (P > 0.05). Immunohistochemical staining indicated that bexarotene treatment decreased cell proliferation and increased apoptosis in tumors. The Rb1/p53 gene-targeted mouse seems to be a valuable model for chemopreventive studies on human small cell lung cancer. Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
You*, Ming
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| Comment |
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| Model Availability: This model is available from |
| Strain |
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