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Model Characteristics - Model:
Rat NG2-expressing glial precursor cells are a new potential
oligodendroglioma cell initiating population in ENU-induced
gliomagenesis
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| Model Descriptor |
Rat NG2-expressing glial precursor cells are a new potential
oligodendroglioma cell initiating population in ENU-induced
gliomagenesis
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| Official Nomenclature |
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| Genotype |
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| Species |
Rat (Rattus norvegicus)
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| Strain |
Sprague-Dawley
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Here, we investigated the cellular origin of low-grade gliomas in a rat model based on transplacental exposure to N-ethyl-N-nitrosourea (ENU). Longitudinal magnetic resonance imaging coupled to immunohistological and immunocytochemical analyses were used to further characterize low-grade rat gliomas at different stages of evolution.
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| Phenotype |
We showed that early low-grade gliomas have characteristics of oligodendroglioma-like tumors and exclusively contain NG2-expressing slow dividing precursor cells, which express early markers of oligodendroglial lineage. These tumor-derived precursors failed to fully differentiate into oligodendrocytes and exhibited multipotential abilities in vitro. Moreover, a few glioma NG2+ cells are resistant to radiotherapy and may be responsible for tumor recurrence, frequently observed in humans. Overall, these findings suggest that transformed multipotent NG2 glial precursor cell may be a potential cell of origin in the genesis of rat ENU-induced oligodendroglioma-like tumors. This work may open up new perspectives for understanding biology of human gliomas.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Baudier*, Jacques
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| Comment |
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| Model Availability: This model is available from |
| Strain |
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