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Model Characteristics - Model:
Effect of silibinin on the growth and progression of primary lung tumors in mice
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| Model Descriptor |
Effect of silibinin on the growth and progression of primary lung tumors in mice
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| Official Nomenclature |
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| Genotype |
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| Species |
Mouse (Mus musculus)
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| Strain |
A/J
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Adenocarcinoma is the most common form of lung cancer in current, former, and never smokers. Murine adenocarcinoma has molecular, histologic, and morphologic similarities to human adenocarcinoma, and the urethane-induced lung carcinogenesis model in A/J mice is frequently employed in chemoprevention studies. An essential requirement for any successful long-term cancer chemoprevention strategy is that the chemopreventive agent has little or no toxicity. An example of such an agent is silibinin, a flavanone from milk thistle (Silybum marianum L.) that is used as a dietary supplement to improve liver function and clinically as an antihepatotoxic drug. There are no published reports of any substantial adverse effects of silibinin when it is given to patients with various liver diseases; rodents fed diets containing silibinin at doses as high as 1% (wt/wt) or 2 g/kg body weight exhibited no toxic effects. br
Silibinin inhibits the growth of tumors in several rodent models. We examined the effects of dietary silibinin on the growth, progression, and angiogenesis of urethane-induced lung tumors in mice.
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| Phenotype |
Urethane-injected mice exposed to silibinin had statistically significantly lower lung tumor multiplicities than urethane-injected mice fed the control diet lacking silibinin. Silibinin inhibits lung tumor angiogenesis in an animal model and merits investigation as a chemopreventive agent for suppressing lung cancer progression.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Agarwal*, Rajesh
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| Comment |
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| Model Availability: This model is available from |
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