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Model Characteristics - Model:
Lkb1-/+ - involvement in endometrial cancer
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| Model Descriptor |
Lkb1-/+ - involvement in endometrial cancer
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| Official Nomenclature |
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| Genotype |
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| Species |
Mouse (Mus musculus)
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| Strain |
FVB
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial malignancies at other sites, including the female reproductive tract.
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| Phenotype |
Female mice heterozygous for a null Lkb1 allele spontaneously develop highly invasive endometrial adenocarcinomas.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Female Only
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| Submitted by |
caMOD, Curator
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| Principal Investigator / Lab |
Castrillon*, Diego H.
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
Stock number |
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 Comments (Please login to submit new comments) |
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